Hydrophilic gels are composed of the internal phase made of a polymer producing a coherent three-dimensional net-like structure, which fixes the liquid vehicle as the external phase. The gels demonstrated thermoreversibility. 2.Pore transport EVALUATION OF QUALITY OF FRESH SOYA-BEAN OIL AVAILABLE IN BANGLADESH, ELECTRONIC TRANSITION IN UV VISIBLE SPECTROSCOPY, QUALITY CONTROL TESTING OF PACKAGING MATERIALS, HERBS USED IN ASTHMA TREATMENT- AN OVERVIEW. Gels are having property to avoid enzymatic activity and drug interaction with food and drinks. E. Hydrophilic gels 5. 4. Medical Dictionary for the Health Professions and Nursing © Farlex 2012 gel A largely liquid colloid, retained in a semisolid state by molecular chains, usually cross-linked. Accessed 26 Oct. 2020. Topical gel synonyms, Topical gel pronunciation, Topical gel translation, English dictionary definition of Topical gel. 'Nip it in the butt' or 'Nip it in the bud'? J. Hydrogel. Define gel. They can avoid the first pass effect, that is, the initial pass of drug substance through the human body. “Gel.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/gel. DELIVERY THROUGH SKIN Kota (RAJ)piyushtripathi1992@rediffmail.com. gel meaning: 1. a thick, clear, liquid substance, especially one used on the hair or body: 2. a thick, clear…. Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. In the presence of water, interactions between the matrix components form a tight gel while the inner core remains unwetted. Occlusivity Formulation Factors  Affecting  Skin Penetration13,21,22: 1. Find another word for gel. Selection of area to be examined carefully during application of gels. 6. They may cause skin allergy during application. 2. At temperatures near the skin surface temperature, the gels softened considerably, this would allow topical application. Define Topical gel. The novel nonaqueous gel exhibited rheological profiles corresponding to a physically cross-linked three dimensional gel network, with suitable mechanical characteristics for use as a vehicle for topical drug delivery. The gel matrices exhibited prominent viscoelastic behavior, yield stress and thixotropy. A. It avoids first-pass effects, gastrointestinal irritation. Molecular conformation of the solvent was found to influence the molecular interactions associated with formation of ethylcellulose gel networks. Ethylcellulose was successfully formulated as a nonaqueous gel with propylene glycol dicaprylate/dicaprate. Gels have possibility of allergenic reactions. Delivered to your inbox! This erosion allows the drug to “back-diffuse” out through the gel-matrix at a controlled rate until the matrix erodes and a majority of the drug is released. Delivery of drugs to the skin is an effective and targeted therapy for local dermatological disorders. It avoid metabolic degradation associated with oral administration. C.  Extended Release Gels: Amphiphilic gels can prepared by mixing the solid gelator like sorbitan monostearate or sorbitan monopalmitate and the liquid phase like liquid sorbitan esters or polysorbate and heating them at 60°C to form a clear isotropic sol phase, and cooling the sol phase to form an opaque semisolid at room temperature. They are applied over skin for slow and prolonged absorption. They avoid systemic and portal circulation following gastrointestinal absorption. Another solid monoester in the sorbitan ester family, sorbitan monopalmitate, also gels organic solvents to give opaque, thermoreversible semisolids. Regional variation 2. Can you spell these 10 commonly misspelled words? F. Non aqueous gels E. Hydrophilic Gels : Gels have also been applied in pharmacy to some viscous suspension for oral use for example Aluminium hydroxide gel. Definition: B. Organogels : 1.Passive diffusion It is a controlled release technology consists of an agglomerated, hydrophilic complex that, when compressed, forms a controlled-release matrix. A colloid in which the disperse phase has combined with the dispersion medium to produce a semisolid material, such as a jelly. A gel is a semi-solid that can have properties ranging from soft and weak to hard and tough. The solvent molecular conformation was found to play a role in affecting the formation of gel networks via intermolecular hydrogen bonding between ethylcellulose polymer chains. Traumatic/pathologic injury to skin Penetration enhancer. 3. Being of current interest or relevance: topical issues. They can substitute for oral administration of medication when the route is unsuitable. Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free! How to use gel in a sentence. Gel: to turn from a liquid into a substance resembling jelly. 8 synonyms of gel from the Merriam-Webster Thesaurus, plus 16 related words, definitions, and antonyms. Rheological and mechanical properties showed significant upward trends with increased polymeric chain length and polymer concentrations. n. 1. Learn more. SUBMIT YOUR ARTICLE/PROJECT AT articles@pharmatutor.org, Subscribe to RSS headline updates from: Powered by FeedBurner, (Click on Subscription link in your inbox), Privacy Policy | Disclaimer | Terms of Use | Advertise | Sitemap | Send Feedback, RECEIVED AWARD AS BEST PHARMA CAREER PORTAL AT ISFCP, Copyright © 2008-2020, PharmaTutor Edu Labs. They can avoid gastrointestinal drug absorption difficulties caused by gastrointestinal pH. Drug delivery to nasal or ocular mucosa for either local or systemic action suffers from many obstacles. Test Your Knowledge - and learn some interesting things along the way. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. The principal mechanisms of drug absorption are: 4. pH Skin hydration They have poor permeability of some drugs through the skin. They are non-invasive and have patient compliance. Drugs of larger particle size do not absorb through the skin. Please tell us where you read or heard it (including the quote, if possible). 'All Intensive Purposes' or 'All Intents and Purposes'?

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